Arginine methylation in global control of RNA splicing and translation

Thousands of proteins undergo arginine N-methylation, a widespread post-translational modification catalyzed by several protein arginine methyltransferases (PRMTs) that covalently link methyl groups to arginine side chains. Nine PRMTs, PRMT1 to PRMT9, have been identified in the human genome, which are further classified into three types according to the final methylarginine products. Arginine methylation plays key roles in various cellular processes.

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