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Single-molecule RNA mapping may reveal how shape shifts steer health and diseaseResearchers from A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new method to study individual RNA molecules and reveal how their structures influence gene regulation, a fundamental process that affects how cells function in health and disease. Their work was published in Nature Methods.... Read more -
Implantable bacteria can now be safely contained, clearing a major hurdle for fighting infection and cancerResearchers have long known that bacteria could potentially be used to deliver therapeutic drugs inside the human body. However, safely and successfully carrying out such a feat in humans has been a challenge. But now, researchers from Harvard have made another step forward toward the goal of using microbes as... Read more -
Bacterial energy enzyme reveals dual-trigger sodium pump mechanism, offering antibiotic cluesThe Na+-NQR enzyme is vital for energy production in pathogenic bacteria like the one that causes cholera, making it a highly promising target for new antibiotics. Researchers combined modified artificial intelligence techniques with extensive supercomputer simulations to visualize the hidden, dynamic movements of this enzyme during sodium transport.... Read more -
Experimentally validated AI model predicts virulence of tomato yellow leaf curl virusA CBBL research team led by Professor Balachandran Manavalan from the Department of Integrative Biotechnology at Sungkyunkwan University has developed DeepTYLCV, an accurate and interpretable artificial intelligence model for predicting the virulence of tomato yellow leaf curl virus (TYLCV).... Read more -
Discovery could reshape RNA editing with DNA-guided CRISPRA team of engineers at the University of Florida has developed a new form of CRISPR technology that could make diagnostics and treatments safer, more precise, and more affordable, while opening the door to entirely new ways of controlling disease.... Read more -
Engineered proteins store digital files with 30 times density at one-tenth costMassive volumes of digital data are generated every day from AI training, big data analytics and smart devices. As conventional hard drives and cloud storage are increasingly constrained by high costs, limited capacity, high power consumption and short lifespans, molecular data storage has emerged as a breakthrough storage alternative.... Read more -
Biodegradable sensors attached to plants detect pesticides in 3 minutesResearchers at the São Carlos Institute of Physics at the University of São Paulo (IFSC-USP) in Brazil, led by Paulo Augusto Raymundo-Pereira, have created biodegradable, "wearable" sensors for plants to monitor their health, including the presence of pesticides. The sensors are made from carbon ink and are screen-printed onto transparent... Read more -
A fresh approach to peppermint: 250 new variants could boost flavor and fight diseaseThe genomics of peppermint are not as fresh as their flavor but scientists from the University of California, Davis, have found a way to breathe new genetic variation into the species. The findings, published in the Proceedings of the National Academy of Sciences, could help the mint industry develop new... Read more -
A new method could help Washington shellfish farmers control a pesky shrimpBurrowing shrimp are small marine excavators native to Washington. They make their homes deep in the sediment by digging, turning the ground to Swiss cheese. This presents a problem for shellfish farmers, whose clams and oysters are often smothered under layers of displaced sediment.... Read more -
Fungus-powered farming delivers higher yields and better-tasting crops, says studyCan we have higher yields and better taste? Using a natural extract from the fungus Pseudozyma aphidis, this method improves the firmness and natural sugar content of crops like tomatoes and melons while significantly boosting production. This discovery offers a practical path to meeting global food demands without compromising the... Read more -
AI tool boosts imperfect antibiotic candidates, with 85% working in lab testsResearchers at the University of Pennsylvania have developed ApexGO, a novel, AI-powered method for turning promising but imperfect antibiotic candidates into more potent ones. Unlike many existing AI approaches to antibiotic discovery, which screen large databases for molecules that might work, ApexGO starts with a small number of imperfect candidates... Read more -
Microalgae can photosynthetically produce and secrete biofuel precursorsMicroalgae have attracted growing attention as a promising platform for sustainable biofuel production because they can use photosynthesis to convert carbon dioxide into energy-rich compounds without competing with food crops. However, practical use of algal biofuels has long faced major obstacles.... Read more -
A marine-inspired sunscreen ingredient made by E. coliHow do fish survive relentless sunlight in the open waters without getting burned? They make their own natural sunscreen—and now, humans could be one step closer to using it too.... Read more -
AI generates first complete models of proteins in motionMany drug and antibody discovery pathways focus on intricately folded cell membrane proteins. When molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior. Understanding how proteins fold and move is therefore essential for developing drugs... Read more -
How can low-value agricultural waste be transformed into high-value products?With plastic pollution at an all-time high, the need for biodegradable materials has never been higher. Most packaging is "single use" and is made from sources, like natural gas, that take hundreds of years to decompose in the environment. This is greatly contributing to the plastic pollution buildup in parks,... Read more
