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Algebraic approach reveals how to restore complex altered gene networksPreviously, research on controlling gene networks has been carried out based on a single stimulus-response of cells. More recently, studies have been proposed to precisely analyze complex gene networks to identify control targets.... Read more
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Researchers discover new microprotein that controls metabolic health in mouse fat cellsLike bees breathing life into gardens, providing pollen and making flowers blossom, little cellular machines called mitochondria breathe life into our bodies, buzzing with energy as they produce the fuel that powers each of our cells. Maintaining mitochondrial metabolism requires input from many molecules and proteins—some of which have yet... Read more
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AI tool targets RNA structures to unravel secrets of the dark genomeWe mapped the human genome decades ago, but most of it is still a black box. Now, UNSW scientists have developed a tool to peer inside and what they find could reshape how we think about disease.... Read more
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An open-source AI platform to democratize protein designSince its release in 2024, the open-source platform BindCraft, developed at EPFL, has already disrupted the world of protein design. Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to control these interactions is of great interest to biologists.... Read more
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Harnessing AI to revolutionize antibiotic discoveryOn a bench in a Philadelphia lab, a robot the size of a microwave clicks through tiny vials, building molecules that existed only as lines of code a week earlier.... Read more
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AI turns simple plant images into early drought warnings, giving crops a voice in the fight against water stressWhat if plants could speak when they were thirsty? Agriculture, in essence, is a dialog among crops, soil and climate. Yet drought, the most insidious stressor, remains largely silent until its damage is visible.... Read more
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A generative AI platform for mRNA therapeuticsRaina Biosciences Inc. (Raina), an mRNA technology and therapeutics company, has released data from its generative AI platform in Science. The data supports Raina's pioneering approach to mRNA design using its GEMORNA platform to generate novel sequences with superior drug properties over existing mRNA discovery methods.... Read more
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AI unlocks secrets of rice yield sustainability after 50 years of continuous croppingAn international research team has uncovered the key drivers of rice yield sustainability by applying artificial intelligence (AI) to the world's longest-running triple-cropping experiment.... Read more
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A tomato line ripe for the picking: Researchers identify 30-year-old variety resistant to diseaseResearchers from USDA's Agricultural Research Service (ARS) and their university partners are helping U.S. tomato growers fight a devastating crop disease. Researchers found that a tomato line developed 30 years ago is showing good resistance to the emerging tomato brown rugose fruit virus (ToBRFV), a virus that has the potential... Read more
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Advanced AI models are not always better than simple ones at predicting genetic perturbation responseEPFL researchers have developed Systema, a new tool to evaluate how well AI models work when predicting the effects of genetic perturbations.... Read more
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Computational tool maps genome change, helping researchers see DNA in 3DNew research from the Wisconsin Institute for Discovery is tackling a complex packing problem. Thanks to the development of a powerful new computational tool introduced in a study published in the journal Genome Research, scientists can better investigate how genomes fit into the tiny confines of a cell nucleus, how... Read more
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In search of the perfect raspberry: Pioneering genome editing technique could be the future of fruit and farmingOne of our most popular summer soft fruits could last longer in the fridge thanks to new research conducted at Cranfield University. In Frontiers in Genome Editing, researchers have published a new method to edit the DNA of raspberries, with the goal of creating more sustainable raspberry production and less... Read more
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Biophysical techniques reveal dynamic movements in RNA-degrading molecular machinesResearchers at the Regensburg Center for Biochemistry (RCB) and the Regensburg Center for Ultrafast Nanoscopy (RUN) at the University of Regensburg are obtaining unique insights into the structure, dynamics and function of dynamic components of the exosome, an RNA-degrading molecular machine in the cell. The results not only provide biological... Read more
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Gene-tweaked albino toads reveal hidden costs of losing pigmentAlbino cane toads created using gene-editing technology reveal that albino animals face competitive disadvantages going far beyond their vulnerability to predators, according to new research published in Proceedings of the Royal Society B: Biological Sciences.... Read more
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Droplet dynamics point way to better spray technology for protecting coral reefsQUT researchers have advanced the understanding of how to create tiny seawater droplets to form mist plumes that reflect sunlight to protect coral reefs.... Read more