RNA in action: Filming ribozyme self-assembly

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure. A recent study published in Nature Communications by Marcia group, has captured, for the first time, a ribozyme in motion—almost frame by frame. The researchers recorded how this tiny RNA machine folds, flexes, and assembles itself, revealing its intricate choreography in unprecedented detail.

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